Skip to main content
. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Oct 13;55(46):14246–14249. doi: 10.1002/anie.201607380

Figure 3.

Figure 3

Distribution of cisplatin–DNA adducts on nuclear DNA. a) Overall distribution of cisplatin sites in the human genome after cisplatin treatment for 3 h, 12 h, or 24 h. b) Relative enrichment of cisplatin crosslinking sites in promoter, intron, TTS, and intergenic regions. c) The enrichment of cisplatin sites on nuclear chromosomes positively correlates with their GG densities (Pearson correlation test, two-sided, correlation value: 0.53, p = 0.009). d) Nucleosome sequencing signals across the cisplatin sites. e) The enrichment of cisplatin–DNA adducts increases with elevated nucleosome density regardless of the GG densities. The area of each circle corresponds to the log value of the cisplatin density. For each column and row, the nucleosome and GG density are fixed, respectively.