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. 2015;61(2):91–100. doi: 10.5387/fms.2015-15

Fig. 2.

Fig. 2.

Therapeutic targeting RAGE/MT1-MMP/Rac1 axis in redox-sensitive signaling pathway in diabetic vascular complications. The schematic diagram shows that MT1-MMP is involved in AGEs/RAGE-dependent, redox-sensitive signaling pathways in cultured SMCs. The MT1-MMP/RAGE complex modifies this pathway and the blockade of RAGE/MT1-MMP axis are candidates for therapeutic strategy. These findings identify the attractive therapeutic targeting for RAGE/MT1-MMP/Rac1 in diabetic vascular complications47).