Fig. 9.

Nitric oxide (NO) generation in the aorta.

Representative electrochemical detection tracing NO concentrations in the isolated aorta from senescence marker protein-30 (SMP30) knockout mice and wild type mice in an organ chamber. The NO concentration is directly proportional to the current (pA), which was measured by a free radical analyzer (Apollo 4000). Acetylcholine-stimulated NO release was attenuated in SMP30 knockout mice vs. wild type mice (p<0.01). ACh indicates acetylcholine administration.