FIGURE 2.

Alignment of the protein structure of the cysteinyl leukotriene 1 (CYSLTR1) and 2 (CYSLTR2) receptors in relation to rhodopsin. The amino acids conserved between these family A receptors are shown. The consensus is greater than 50%. These data formed the basis of the model predicting the CYSLTR1 and CYSLTR2 transmembrane domains (helices 1–7), the four β-sheets, and the putative cysteinyl leukotriene-binding domain. The amino acid variants that are associated with atopy or asthma, the G300S CYSLTR1variant, and the M201V CYSLTR2 variant are each boxed and noted with arrows (adapted from Thompson et al., 2014a).