Table 3.

CYSLTR2 receptor variants: naturally occurring polymorphisms and in vitro engineered mutants.

Nucleotide position	Type	SNP access code	Disease association	Reference
g.-1220A/C c.-819 T > G c.2078 C > T c.2534A > G c.3105 A/G (Exon1-UTR) c.-2534A > G c.601 A/G	Promotor Haplotype Haplotype Coding	rs1323552 rs912278 rs41347648	Associated with asthma Aspirin intolerant asthma Stronger association with LTC4S c.-444A > C Not associated with atopic dermatitis Not associated 201Ser is associated with atopic asthma 201Ser is a hypomorphic variant; decreased Ca2+ flux Common allele associated with protection against atopy Associated with atopy; Hypomorphic 201Ser is hypomorphic Decreased LTD4 binding Decreased inositol phosphate production	Fukai et al., 2004 Park et al., 2005 Kato et al., 2011 Kumar et al., 2012 Thompson et al., 2003 Thompson et al., 2006 Pillai et al., 2004 Brochu-Bourque et al., 2011

aa, amino acid; IC, intracellular loop; SNP, single nucleotide polymorphism; TM, transmebrane helix. Approximate allele frequency as reported by the Exome Aggregation Consortium (ExAC), Cambridge, MA, USA (http://exac.broadinstitute.org).