Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 22;6:37196. doi: 10.1038/srep37196

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

The holding potential was minus sixty millivolt in the analyses. (A) Control: Original recordings from control neuron. (B) Control+ADPR group: DRG isolated from rats of control and sham groups without ISC induction and they were stimulated by capsaicin (0.01 mM) and ADPR (1 mM) but inhibited by ACA (0.025 mM). (C) ISC+ADPR group: TRPM2 currents in the DRG neurons of ISC-induced rats were gated by ADPR (1 mM) in the patch pipette and they were inhibited by ACA in the bath of patch chamber. (D) DEX+ADPR group: The rats received intraperitoneal DEX and then the DRG neurons were stimulated by in vitro ADPR (1 mM in patch pipette). (E) ISC+DEX+ADPR group: The rats received DEX at 3^rd, 24^th and 48^th hours after induction of experimental ISC and then the DRG was stimulated by ADPR (1 mM). (B) I-V and (C) I-V: Current voltage relationships and they are same experiments as in panels B and C, respectively. W.C. is whole-cell. (F) TRPM2 channel capacitance of the DRG in control and ISC-induced rats (mean ± SD). The DRG neurons were further treated in vitro afterwards with ADPR (1 mM) and ACA (0.025 mM). Capacitance calculation of the currents was described in the method section. The numbers of group were indicated in parentheses. (^ap ≤ 0.001 versus control. ^bp ≤ 0.001 versus control+ADPR group. ^cp ≤ 0.001 versus control+ADPR+ACA group. ^cp ≤ 0.001 versus ISC+ADPR group. ^ep ≤ 0.001 versus ISC+ADPR+ACA group).