Figure 5. Effects of dexmedetomidine (DEX) treatments on apoptosis and MTT levels through TRPV1 and TRPM2 channel activities in HIPPO neurons of ischemia (ISC)-induced rats [mean ± SD and n = 12 except control (n = 8)].

The HIPPO neurons were further treated in vitro afterwards with CHPx (1 mM) (Fig. 5A) and CAP (0.01 mM) (Fig. 5B) although they were inhibited by ACA (0.025 mM) and CPZ (0.1 mM) and, respectively. Values were expressed as fold-increase (experimental/control). (^ap ≤ 0.05 and ^bp ≤ 0.001 vs control, sham and DEX groups. ^cp ≤ 0.001 and ^dp ≤ 0.05 vs DEX+ACA and DEX+CPZ group. ^ep ≤ 0.001 vs ISC group. ^fp ≤ 0.05 vs ISC+ACA and ISC+CPZ group. ^gp ≤ 0.05 vs ISC+DEX group).