Table 1.
Functional pathways of TDP-43-associated RNAs most likely to exert a meaningful effect on neurons
| Gene | RNA fold change (TDPKO vs. ctrl) | Pathway |
|---|---|---|
| Cacna1b | −2.5 | Synaptic |
| Dlg3 | −2.7 | Synaptic |
| Pitpnm3 | −2.4 | Synaptic |
| Ralgps2 | −2.6 | Synaptic |
| Vps13d | −2.4 | Synaptic |
| Mrps6 | −1.6 | Mitochondrial |
| Tecpr1 | −4 | Autophagy |
| Crem | −2.5 | General signaling |
| Brms1l | −2.1 | Transcription/translation |
| Celf5 | −2.4 | Transcription/translation |
| Abr | −2.9 | Unclear |
RNAs were selected if their absolute value fold change >1.5 in TDP-43 KO brains compared to control. Pathways in bold have been strongly implicated in the early pathogenesis of AD. The RNA sequencing data were generated from 3-month cT mice [26], and the associated functional pathways in neurons were identified using GeneCards and confirmed by the manual literature search