Table 3.
Unadjusted and Adjusted Associations Between Serum PFAS and Menstrual Cycle Length Estimated Using Bayesian Joint Model, LIFE Study, 2005-2009.
| Single PFAS Modela |
Multiple PFAS Modelb |
|||
|---|---|---|---|---|
| PFAS (ng/mL) | Unadjusted AF (95% CrI) |
Adjustedc AF (95% CrI) |
Adjustedd AF (95% CrI) |
Adjustede AF (95% CrI) |
| PFOSA | ||||
| ≥LOD (≥ 0.10) | 0.99 (0.96, 1.02) | 0.99 (0.96, 1.02) | 0.99 (0.95, 1.02) | 0.98 (0.95, 1.02) |
| Et-PFOSA-AcOH | ||||
| ≥Q3 (≥ 0.06) | 1.00 (0.97, 1.02) | 1.01 (0.99, 1.04) | 1.00 (0.97, 1.03) | 1.01 (0.98, 1.04) |
| Me-PFOSA-AcOH | ||||
| Tertile 2 (0.02-0.03) | 0.97 (0.94, 0.99) | 0.98 (0.95, 1.01) | 0.97 (0.94, 1.00) | 0.98 (0.95, 1.00) |
| Tertile 3 (≥ 0.04) | 0.99 (0.96, 1.01) | 1.00 (0.97, 1.03) | 0.99 (0.96, 1.02) | 1.00 (0.96, 1.02) |
| PFDeA | ||||
| Tertile 2 (0.03-0.04) | 1.03 (1.00, 1.05) | 1.03 (1.00, 1.05) | 1.02 (0.99, 1.05) | 1.03 (1.00, 1.07) |
| Tertile 3 (≥ 0.05) | 1.00 (0.98, 1.03) | 1.01 (0.99, 1.04) | 0.99 (0.95, 1.02) | 1.02 (0.98, 1.06) |
| PFNA | ||||
| Tertile 2 (0.10-1.40) | 1.02 (0.99, 1.04) | 1.02 (0.99, 1.04) | 1.03 (0.99, 1.06) | 1.02 (0.98, 1.05) |
| Tertile 3 (≥ 1.50) | 1.00 (0.98, 1.03) | 1.01 (0.99, 1.04) | 1.03 (0.99, 1.07) | 1.02 (0.98, 1.06) |
| PFOS | ||||
| Tertile 2 (9.50-15.10) | 1.01 (0.98, 1.03) | 1.01 (0.98, 1.03) | 1.01 (0.98, 1.05) | 1.02 (0.99, 1.04) |
| Tertile 3 (≥ 15.20) | 1.00 (0.98, 1.03) | 1.01 (0.98, 1.03) | 1.02 (0.99, 1.06) | 1.02 (0.99, 1.06) |
| PFOA | ||||
| Tertile 2 (2.50-4.10) | 0.97 (0.95, 1.00) | 0.98 (0.95, 1.01) | 0.95 (0.93, 0.97) | 0.95 (0.93, 0.99) |
| Tertile 3 (≥ 4.20) | 0.98 (0.95, 1.00) | 0.98 (0.96, 1.00) | 0.96 (0.93, 0.98) | 0.95 (0.92, 0.98) |
AF indicates acceleration factor; CrI credible interval; Et-PFOSA-AcOH, 2-(N-ethyl-perfluorooctane sulfonamido) acetate; LOD, limit of detection; Me-PFOSA-AcOH, 2-(N-methyl-perfluorooctane sulfonamido) acetate; PFAS, perfluoroalkyl substance; PFDeA, perfluorodecanoate; PFNA, perfluorononanoate; PFOSA, perfluorooctane sulfonamide; PFOS, perfluorooctane sulfonate; PFOA, perfluorooctanoate; Q3, 75th percentile.
PFOSA and Et-PFOSA-AcOH concentrations were dichotomized a priori as above/below the LOD and separately above/below Q3, respectively. All other PFASs were categorized a priori into tertiles.
AF represents the relative change in menstrual cycle length compared to the reference group (lowest PFAS concentration, not shown), conditional on the random effect. An AF>1 represents an increase in cycle length while an AF<1 represents a decrease in cycle length.
Separate models were run for each PFAS.
One model was run incorporating all PFASs.
Associations adjusted for female age, BMI, and active smoking at enrollment.
Associations adjusted for remaining PFASs.
Associations adjusted for female age, BMI, active smoking at enrollment and remaining PFASs.