Table 4.
Associations Between Serum PFAS and Day-Specific Probability of Pregnancy With Adjustment for Cycle Length Estimated Using Bayesian Joint Model, LIFE Study, 2005-2009.
| Single PFAS Modela |
Multiple PFAS Modelb |
|||
|---|---|---|---|---|
| Covariate | Adjustedc OR (95% CrI) |
Adjustedd OR (95% CrI) |
Adjustede OR (95% CrI) |
Adjustedf OR (95% CrI) |
| Cycle Length | ||||
| Linear (days) | 1.5 (1.1, 2.1) | 1.4 (1.0, 1.9) | 1.5 (1.1, 2.1) | 1.5 (1.1, 2.2) |
| Quadratic (days2) | 0.7 (0.5, 0.8) | 0.7 (0.6, 0.9) | 0.7 (0.6, 0.9) | 0.8 (0.6, 0.9) |
| PFAS (ng/mL) | ||||
| PFOSA | ||||
| ≥LOD (≥ 0.10) | 0.6 (0.4, 1.1) | 0.6 (0.3, 1.1) | 0.6 (0.3, 1.1) | 0.6 (0.3, 1.0) |
| Et-PFOSA-AcOH | ||||
| ≥Q3 (≥ 0.06) | 0.8 (0.5, 1.2) | 0.9 (0.6, 1.3) | 0.9 (0.6, 1.3) | 0.9 (0.6, 1.3) |
| Me-PFOSA-AcOH | ||||
| Tertile 2 (0.02-0.03) | 1.1 (0.7, 1.6) | 1.1 (0.7, 1.7) | 1.1 (0.7, 1.6) | 1.1 (0.7, 1.6) |
| Tertile 3 (≥ 0.04) | 0.9 (0.6, 1.4) | 1.0 (0.7, 1.4) | 1.0 (0.6, 1.5) | 1.0 (0.6, 1.5) |
| PFDeA | ||||
| Tertile 2 (0.03-0.04) | 0.7 (0.5, 1.1) | 0.7 (0.5, 1.1) | 0.9 (0.5, 1.5) | 0.9 (0.5, 1.4) |
| Tertile 3 (≥ 0.05) | 0.9 (0.6, 1.2) | 0.9 (0.6, 1.3) | 1.4 (0.7, 2.6) | 1.4 (0.7, 2.5) |
| PFNA | ||||
| Tertile 2 (0.10-1.40) | 0.7 (0.4, 1.0) | 0.7 (0.5, 1.0) | 0.6 (0.4, 1.1) | 0.6 (0.4, 1.0) |
| Tertile 3 (≥ 1.50) | 0.8 (0.5, 1.1) | 0.8 (0.6, 1.2) | 0.7 (0.4, 1.3) | 0.7 (0.3, 1.1) |
| PFOS | ||||
| Tertile 2 (9.50-15.10) | 1.0 (0.6, 1.4) | 1.0 (0.7, 1.5) | 1.3 (0.8, 2.0) | 1.2 (0.8, 1.8) |
| Tertile 3 (≥ 15.20) | 0.9 (0.6, 1.2) | 0.9 (0.6, 1.3) | 1.1 (0.7, 1.9) | 1.1 (0.7, 1.8) |
| PFOA | ||||
| Tertile 2 (2.50-4.10) | 0.9 (0.6, 1.4) | 1.0 (0.7, 1.5) | 1.0 (0.6, 1.6) | 1.1 (0.7, 1.7) |
| Tertile 3 (≥ 4.20) | 0.7 (0.5, 1.0) | 0.7 (0.5, 1.1) | 0.7 (0.4, 1.2) | 0.7 (0.4, 1.2) |
CrI indicates credible interval; Et-PFOSA-AcOH, 2-(N-ethyl-perfluorooctane sulfonamido) acetate; LOD, limit of detection; Me-PFOSA-AcOH, 2-(N-methyl-perfluorooctane sulfonamido) acetate; OR, odds ratio; PFAS, perfluoroalkyl substance; PFDeA, perfluorodecanoate; PFNA, perfluorononanoate; PFOSA, perfluorooctane sulfonamide; PFOS, perfluorooctane sulfonate; PFOA, perfluorooctanoate; Q3, 75th percentile.
PFOSA and Et-PFOSA-AcOH concentrations were dichotomized a priori as above/below the LOD and separately above/below Q3, respectively. All other PFASs were categorized a priori into tertiles.
OR is the exponentiated coefficient in the model for day-specific probability of pregnancy. For the PFASs, the reference group is the group with the lowest PFAS concentration (not shown).
Separate models were run for each PFAS.
One model was run incorporating all PFASs.
Associations adjusted for couple intercourse pattern and female menstrual cycle length.
Associations adjusted for couple intercourse pattern, female menstrual cycle length, age, BMI, and active smoking at enrollment.
Associations adjusted for couple intercourse pattern, female menstrual cycle length and remaining PFASs.
Associations adjusted for couple intercourse pattern, female menstrual cycle length, age, BMI, active smoking at enrollment and remaining PFASs.