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Application of MeTIR to the metal-directed Zn4:MBPC14 tetramer (PDB ID: 2QLA) to give Zn4:RIDC14 (PDB ID: 3HNI). Red axes denote the C2-symmetric interfaces i1, i2 and i3. The redesigned i1 residues are shown as cyan sticks. Metal-coordinating ligands are shown as gray sticks. Zn2+ ions are shown as gray spheres. Beneath are close-up views of the i1 PPIs between two MBPC1 or RIDC1 protomers within the Zn-bound tetramers.
