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. 2016 Nov 1;30(21):2345–2369. doi: 10.1101/gad.289140.116

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© 2016 van der Knaap and Verrijzer; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Histone methylation and demethylation. (A) Histones are methylated by KMTs, which require SAM as a cosubstrate. Two different classes of KDMs can remove a methyl group. LSD1/2 require FAD as an electron acceptor. The JmjC domain-containing KDMs use αKG as a cosubstrate. Fumarate, succinate, and R-2HG are competitive inhibitors. (FADH₂) FAD, reduced; (Me) methyl. (B) Schematic representation of folate-mediated one-carbon metabolism in the cytosol. (hCys) Homocysteine; (Met) methionine; (NADP⁺) NAD phosphate.