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. 2016 Dec;26(12):1710–1720. doi: 10.1101/gr.209247.116

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© 2016 Carvalho et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Contiguity of assemblies produced with different methods. (M) standard MHAP; (L) MHAP with low-frequency k-mer masking; (LH) MHAP with low and high frequency k-mer masking. (A) Assembly of simple genomes under the challenging conditions of low coverage (E. coli; coverage reduced from 94× to 30×) or small sketch size (yeast; MHAP sketch size reduced from 512 to 128). (B) Assembly of three complex genomes (C. elegans, A. thaliana, and D. melanogaster).