. Author manuscript; available in PMC: 2017 Apr 17.

Published in final edited form as: Nat Genet. 2016 Oct 17;48(12):1544–1550. doi: 10.1038/ng.3685

Table 3.

Associations of DRB1*1301-DQA1*0103-DQB1*0603 haplotype in individuals with >70% Caucasian ancestry

							Meta-analysis^c
	haplotype^a case/control	case/control	HF^b case	HF^b control	OR	P	OR	P
Oral and pharynx cancer							0.68	3.32x10^–10
Europe	207/422	2,497/2,928	0.04	0.07	0.60	4.04x10^–8
North America	207/276	2,342/2,329	0.04	0.06	0.74	1.68x10^–3
South America	74/101	613/727	0.06	0.07	0.86	0.35

Oral cancer							0.75	1.72x10^–4
Europe	106/422	1,231/2,928	0.04	0.07	0.60	1.52x10^–5
North America	128/276	1,135/2,329	0.06	0.06	0.92	4.67x10^–1
South America	41/101	351/727	0.06	0.07	0.80	0.26

Oropharynx cancer							0.59	2.73x10^–9
Europe	84/422	1,098/2,928	0.04	0.07	0.57	2.69x10^–5
North America	72/276	1,119/2,329	0.03	0.06	0.52	3.49x10^–6
South America	31/101	216/727	0.07	0.07	1.05	0.81

Oropharynx cancer by HPV status ^d
HPV-positive	11/505	336/3,686	0.01	0.07	0.23	1.6x10^–6
HPV-negative	25/505	240/3,686	0.05	0.07	0.75	0.16

Number of copies of the haplotype in cases and controls

Haplotype frequency calculated as total number of copies of haplotype in the population (haplotype copies/2n).

Fixed-effects meta-analysis of regional associations adjusted for age, sex and eigenvectors.

HPV-status available in a subset of cases from ARCAGE, EPIC, CHANCE and Pittsburgh studies