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. Author manuscript; available in PMC: 2017 Apr 24.
Published in final edited form as: Nat Neurosci. 2016 Oct 24;19(12):1619–1627. doi: 10.1038/nn.4428

Figure 1. Neuronal activity evokes capillary dilation.

Figure 1

(a) A cortical capillary response to 200 nM U46619 and superimposed neuronal stimulation (stim). Lines show lumen diameters plotted in b. (b) U46619 evoked constriction and stimulation-evoked dilation at regions indicated in a (in this and subsequent example traces, a large response is shown for illustrative purposes). (c) 500 nM TTX blocks stimulation-evoked capillary dilation. (d) 10 µM NBQX blocks stimulation-evoked dilation. (e) 25 µM D-AP5 did not reduce stimulation-evoked dilation. (f-h) Mean data showing the block of capillary dilation by TTX (f) and NBQX (g) but not by D-AP5 (h). Numbers on bars are capillary regions (putative pericytes) studied. Data are shown as box and whisker plots as defined in the Statistics part of the Methods.