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. Author manuscript; available in PMC: 2017 Apr 24.
Published in final edited form as: Nat Neurosci. 2016 Oct 24;19(12):1619–1627. doi: 10.1038/nn.4428

Figure 5. PLD2, not PLA2, initiates neurovascular coupling at the capillary level.

Figure 5

(a) The PLA2 inhibitor MAFP (10 μM) does not block stimulation-evoked capillary dilation. (b) The PLC blocker, U73122 (10 μM), does not reduce dilation. (c) The PLD blocker FIPI (1 μM) inhibits dilation. (d-f) Mean data showing the effects of MAFP (d), U73122 (e) and FIPI (f) on capillary dilation. (g) Blocking PLD1 with VU0155069 (500 nM) had no effect on the dilation. (h-i) The PLD2 blocker CAY10594 (1 μM; h) and the DAGL blocker RHC80267 (50 μM; i) significantly reduce the capillary dilation. (j-l) Mean data showing the effect of VU0155069 (j), CAY10594 (k) and RHC80267 (l) on capillary dilation. Data are shown as box and whisker plots as defined in the Statistics part of the Methods.