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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: IEEE Trans Biomed Eng. 2016 Jul 18;63(10):2015–2020. doi: 10.1109/TBME.2016.2591960

Fig. 1.

Fig. 1

Three requirements for reproducible systems biology modeling. (1) The provenance of every data source and assumption should be recorded so that models can be regenerated, including every species, reaction, and rate law. (2) Every simulation parameter value should be recorded so that numerical simulation results can be regenerated. (3) Multiple simulation software tools should generate statistically identical numerical results. Reproducibility is a stricter standard than repeatability. Models are considered repeatable, but not reproducible, if they satisfy just the second and third criteria.