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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Toxicology. 2016 Jul 6;361-362:39–48. doi: 10.1016/j.tox.2016.07.004

Fig. 3.

Fig. 3

Microarray analyses. A: Unsupervised hierarchical cluster analyses of liver tissue from MetKO mice or WT fed with the high-cholesterol (HC) diet for 30 days. A total of 1245 differentially expressed genes were identified using bootstrap t-test with 10,000 repetitions (p-value ≤ 0.01). B: Top signaling pathways in livers from MetKO mice fed with HC or normal chow diets as determined by IPA analysis. C: Top toxicological functions affected in MetKO mice fed with HC diet as determined by IPA analysis.