Skip to main content
. 2016 Dec 1;12(12):e1005979. doi: 10.1371/journal.ppat.1005979

Fig 1. Distribution and conservation of competence pathways in Streptococcus spp.

Fig 1

(Top) The Type-I ComRS pathway is found in the Salivarius group (yellow shading) and the ComCDE pathway in the Anginosus and Mitis groups (blue shading). The Type-II ComRS pathway is present in Bovis, Mutans, and Pyogenic groups of Streptococcus (red shading). The Suis group, or Type-III ComRS pathway (violet), contains attributes distinguishable from Type-I and Type-II. Underlined species indicate the demonstration of natural competence under laboratory conditions. (Bottom) The putative XIP sequences from the Type-II ComRS pathway demonstrate a conserved double tryptophan motif. Represented sequences were derived from small ORFs directly downstream of ComR and include the C-terminal 7 or 8 amino acids predicted to encode the mature pheromone. aThe ComR derived from S. agalactiae NEM316 was not investigated, however this species does encode a putative Type-II XIP. bThe S. suis 05ZYH33 XIP represents a Type-III XIP encoding two tryptophan residues (in green) interrupted by glycine and threonine. cThe S. thermophilus LMD-9 Type-I XIP, lacking a WW-motif, is included for reference.