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. 2016 Dec 1;11(12):e0167287. doi: 10.1371/journal.pone.0167287

Fig 1. RAGE deficiency did not influence the clinical severity and frequency of septic arthritis but impaired bacterial clearance in staphylococcal sepsis.

Fig 1

The clinical severity of arthritis (A), the frequency of arthritis (B), and changes in the body weight (C) in Receptor for Advanced Glycation End products deficient (RAGE-/-) and wild-type (WT) mice after intravenous infection with S. aureus LS-1 strain. The data are reported as mean ± SEM and analyzed with Mann-Whitney U test and Fisher's exact test. Persistence of S. aureus in the kidneys (D) of WT mice (n = 27) and RAGE-/- mice (n = 27) at the end of septic arthritis experiments as well as in WT mice (n = 7) and RAGE-/- mice (n = 13) surviving the sepsis experiment. The results of the bacterial count are expressed as colony forming units (CFU) and the data are reported as median and interquartile range (IQR).