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. 2016 Dec 1;11(12):e0167287. doi: 10.1371/journal.pone.0167287

Fig 2. RAGE deficient mice with septic arthritis presented similar radiological and histopathological joint destructions as wild-type mice.

Fig 2

The radiological accumulative bone destruction scores (A), the frequency of bone destructions (B) and the frequency of polyarthritis (C) in WT and RAGE-/- mice as evaluated by micro-CT scan. The data are reported as mean ± SEM and analyzed with Mann-Whitney U test and Fisher's exact test. Representative micro-CT scan images (D) of wrist joints from RAGE-/- mice illustrating a healthy joint (left panel) and a joint with severe septic arthritis (right panel). The erosions are indicated by the arrows. Histopathologic evaluation of synovitis and bone erosions (E) in the joints from all 4 limbs of WT mice (n=7) and RAGE-/- mice (n=8) on day 14 post-infection. The data are reported as mean ± SEM and analyzed with Mann-Whitney U test. Illustrative photomicrographs (F) showing a healthy wrist joint from RAGE-/- mouse (left panel) and a heavily inflamed wrist joint with severe bone and cartilage destruction from WT mouse (right panel). Histologic staining was performed using hematoxylin and eosin. The asterisk indicates an inflamed synovium. Abbreviations: B, bone; C, cartilage; E, erosion of bone and cartilage; JC, joint cavity; S, synovial tissue. Original magnification × 25.