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. 2016 Dec 1;11(12):e0166909. doi: 10.1371/journal.pone.0166909

Table 3. Independent predictors of pregnancy outcomes.

Predictor Univariate Adjusted1
Odds ratio 95% CI P-value Odds ratio 95% CI p-value
Diagnosis <.001 <.001
Normal chromosomes 1 1
Aneuploidy 304.50 250.98–369.44 <.001 437.40 348.19–549.46 <.001
Other anomaly 97.00 72.43–129.91 <.001 95.94 69.21–133.01 <.001
Year <.001 .972
2000–2003 1 1
2004–2007 1.27 1.12–1.44 <.001 0.98 0.79–1.22 .874
2008–2011 1.37 1.20–1.55 <.001 0.97 0.78–1.22 .815
Age
<35 1 1
≥35 0.59 0.53–0.65 <.001 0.35 0.28–0.42 <.001
SIMD .001 .221
1 (least affluent) 1 1
2 0.98 0.81–1.18 .822 1.24 0.91–1.70 .174
3 0.73 0.60–0.88 .001 0.88 0.64–1.21 .434
4 0.77 0.64–0.92 .003 0.99 0.73–1.34 .934
5 (most affluent) 0.84 0.71–0.99 .040 1.10 0.82–1.47 .538
Parity .037
0 1 1
1 0.81 0.72–0.92 .001 0.86 0.70–1.06 .159
≥2 0.79 0.69–0.90 .001 0.73 0.58–0.93 .011

CI confidence interval; SIMD Scottish Index of Multiple Deprivation.

1Adjusted for diagnosis, year of testing, maternal age, SIMD quintiles, parity