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. 2016 Dec 1;11(12):e0167077. doi: 10.1371/journal.pone.0167077

Fig 2. Whole blood SMN levels at P12, P30, and P90.

Fig 2

SMN levels were between ASO-treated SMA mice and untreated SMA, ASO-treated Het mice, and untreated Het mice. At P12, SMN levels were increased in ASO-SMA mice (n = 11) compared to SMA mice (n = 13) but reduced compared to ASO-Het (n = 10) and Het mice (n = 4). Untreated SMA mice have a mean survival of ~2 weeks. Therefore no SMA disease control animals are available for comparison at P30 or P90. At P30 SMN levels were diminished in ASO-SMA mice (n = 10) compared to ASO-Het (n = 5) and Het (n = 8) mice. At P90, SMN levels in ASO-SMA mice (n = 11) were reduced compared with ASO-Het (n = 6) but not Het (n = 8) mice. *, p<0.05, ***, p<0.001 (Note the different scale for P12, P30, and P90 SMN levels).