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. 2016 Nov 28;68(12):2936–2944. doi: 10.1002/art.39792

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© 2016 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Principal components analysis of genome‐wide DNA methylation in all labial salivary gland tissue samples, including replicates. The first principal component (PC1) separates Sjögren's syndrome cases from controls, with samples from the 2 subjects with intermediate phenotype (ocular staining score ≥3 in at least 1 eye) between those of the cases and the controls. PC2 represents a spread of sample DNA methylation states orthogonal to the primary case–control contrast. This axis may represent biologic intrapatient heterogeneity. All study subjects were women of genetically confirmed European descent who were participants in the Sjögren's International Collaborative Clinical Alliance Registry.