Table 3.
Differentially methylated CpG sets in labial salivary glands from Sjögren's syndrome patientsa
| MSigDB gene set | Differentially methylated promoters | Adjusted P |
|---|---|---|
| Immune response (GO:0006955) | CCR6, BST2, AIM2, LCP2, CD79B, MADCAM1 | 2.9 × 10−8 |
| Intrinsic to plasma membrane (GO:0031226) | TNFRSF13B, MTNR1A, CCR6, BST2, CXCR5, NCKAP1L, CD160, CD19, CD79B, IL12RB1 | 1.7 × 10−7 |
| Genes with promoters containing Ets2 motif RYTTCCTG (M14654) | PTPRCAP, TNFRSF13B, KCNQ1DN, RUNX3, FERMT3, LCP1, SPI1, SLAMF1, CD19, ERG, PIK3CG | 3.6 × 10−7 |
| Immune system process (GO:0002376) | CCR6, BST2, AIM2, SPI1, LCP2, CD79B, MADCAM1 | 1.0 × 10−6 |
| Cell surface receptor–linked signal transduction (GO:0007166) | TNFRSF13B, MTNR1A, CXCR5, CD160, GNB3, LCP2, CD19, IL12RB1, PIK3CG | 2.9 × 10−6 |
| Genes with promoters containing PU.1 motif WGAGGAAG (M14376) | PTPRCAP, LTA, NCKAP1L, LCP2, NR1H3, PIK3CG | 4.7 × 10−5 |
| Signal transduction (GO:0007165) | LTA, TNFRSF13B, MTNR1A, CCR6, BST2, CXCR5, CD160, GNB3, BLK, LCP2, CD19, ERG, IL12RB1, KALRN, MADCAM1, PIK3CG | 2.8 × 10−4 |
a
These gene sets from the Molecular Signatures Database (MSigDB) were selected as candidates for CpG enrichment because they contained a significantly high fraction of differentially methylated promoters, as shown here. Bonferroni‐adjusted P values are reported for hypergeometric CpG set enrichment tests.