Table 6.
Incidence of Laboratory Abnormalities, any Causality
| Event,a n (%) | AP CML (n = 79) | BP CML (n = 64) | ALL (n = 24) | Total (n = 167) | ||||
|---|---|---|---|---|---|---|---|---|
| All grades | Grade 3/4 | All grades | Grade 3/4 | All grades | Grade 3/4 | All grades | Grade 3/4 | |
| Hematologic laboratory abnormalitiesa | ||||||||
| Anemia | 78 (99) | 28 (35) | 60 (94) | 25 (39) | 22 (92) | 7 (29) | 160 (96) | 60 (36) |
| Thrombocytopenia | 64 (81) | 39 (49) | 50 (78) | 42 (66) | 20 (83) | 18 (75) | 134 (80) | 99 (59) |
| Neutropenia | 50 (63) | 18 (23) | 44 (69) | 37 (58) | 20 (83) | 12 (50) | 114 (68) | 67 (40) |
| Leukopenia | 39 (49) | 11 (14) | 42 (66) | 28 (44) | 16 (67) | 9 (38) | 97 (58) | 48 (29) |
| Lymphopenia | 38 (48) | 12 (15) | 39 (61) | 18 (28) | 12 (50) | 11 (46) | 89 (53) | 41 (25) |
| Other laboratory abnormalities occurring in ≥30% of patients, any cohort | ||||||||
| Hypocalcemia | 32 (41) | 4 (5) | 35 (55) | 3 (5) | 9 (38) | 1 (4) | 76 (46) | 8 (5) |
| Elevated alkaline phosphatase | 30 (38) | 1 (1) | 25 (39) | 1 (2) | 15 (63) | 0 | 70 (42) | 2 (1) |
| Hyperglycemia | 30 (38) | 7 (9) | 26 (41) | 2 (3) | 13 (54) | 1 (4) | 69 (41) | 10 (6) |
| Elevated INR | 31 (39) | 2 (3) | 30 (47) | 0 | 10 (42) | 1 (4) | 71 (43) | 3 (2) |
| Elevated ALT | 36 (46) | 7 (9) | 20 (31) | 1 (2) | 11 (46) | 0 | 67 (40) | 8 (5) |
| Elevated AST | 34 (43) | 4 (5) | 19 (30) | 1 (2) | 5 (21) | 0 | 58 (35) | 5 (3) |
| Elevated creatinine | 25 (32) | 0 | 22 (34) | 1 (2) | 9 (38) | 0 | 56 (34) | 1 (1) |
| Hypophosphatemia | 30 (38) | 6 (8) | 17 (27) | 4 (6) | 9 (38) | 3 (13) | 56 (34) | 13 (8) |
| Elevated PTT | 26 (33) | 2 (3) | 21 (33) | 2 (3) | 5 (21) | 0 | 52 (31) | 4 (2) |
| Hypokalemia | 18 (22) | 3 (4) | 22 (34) | 4 (6) | 12 (50) | 0 | 52 (31) | 7 (4) |
| Elevated prothrombin time | 23 (29) | 2 (3) | 20 (31) | 0 | 3 (13) | 0 | 46 (28) | 2 (1) |
| Hyponatremia | 16 (20) | 3 (4) | 22 (34) | 6 (9) | 5 (21) | 1 (4) | 43 (26) | 10 (6) |
| Hypoalbuminemia | 18 (23) | 0 | 24 (38) | 2 (3) | 5 (21) | 1 (4) | 47 (28) | 3 (2) |
a
Many patients had cytopenias when they started the study.
AP, accelerated phase; CML, chronic myeloid leukemia; BP, blast phase; ALL, acute lymphoblastic leukemia; ALT, alanine aminotransferase; INR, international normalized ratio; AST, aspartate aminotransferase; PTT, partial thromboplastin time.