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Pharmacokinetic Parameters of a 6.25 mg/kg Dose of Defibrotide in Healthy Japanese Subjects
| Cmax (μg/mL) | Tmax (h) | kel (1/h) | T1/2 (h) | AUC0–3 (μg·h/mL) | AUC0–∞ (μg·h/mL) | (CL)tot (L/h) | Vd (L) | |
|---|---|---|---|---|---|---|---|---|
| n | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| Mean | 20.59 | 2.00 | 1.55 | 0.47 | 37.09 | 42.32 | 9.27 | 7.31 |
| SD | 4.11 | 0.00 | 0.33 | 0.10 | 7.82 | 6.95 | 1.18 | 1.25 |
kel, elimination rate constant, Vd, volume of distribution.
