Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 7;88(3):361–374. doi: 10.1111/tpj.13252

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Model of cis‐ and trans‐regulation of defence gene responsiveness by DNA (de)methylation.

Responsiveness of defence genes can be cis‐regulated via RNA‐directed DNA methylation (RdDM; blue) and/or ROS1‐mediated DNA demethylation (red) of nearby DNA regions, such as transposable elements (TEs; purple). Trans‐regulation of defence genes that are not associated with nearby DNA methylation can be achieved via different mechanisms. Apart from indirect regulation by cis‐controlled regulatory genes (top), chromatin remodellers in the RdDM protein complex can cross‐link with distant genomic regions and influence post‐translational histone modifications at distal genes that are not associated with DNA methylation. Red arrows indicate stimulation of DNA methylation and/or post‐translational histone modifications (blue triangles and circles) by the RdDM complex. Green lines indicate repression of DNA methylation by ROS1, or transcriptional repression by post‐translational histone modifications. The black arrow indicates stimulation of defence gene induction by defence regulatory proteins.