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. 2016 Nov 23;31(11):1888–1894. doi: 10.1111/jgh.13388

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© 2016 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The effects of spleen removal on pulmonary angiogenesis and gas exchange in experimental hepatopulmonary syndrome. Lung microvessels were stained by Factor VIII (in green) and counted in common bile duct ligation (CBDL) animals with or without splenectomy. (a) Representative immunofluorescent images of Factor VIII; (b) quantitation of Factor VIII‐stained microvessels; (c) graphical summaries of lung vascular endothelial growth factor‐A (VEGF‐A) mRNA levels; and (d) arterial gas exchange was assessed by the alveolar–arterial oxygen gradient (AaPO₂). Splenectomy significantly decreased lung microvessel numbers and VEGF‐A levels and improved AaPO₂ after CBDL. Values are expressed as means ± SE (n = 6–8 animals for each group). ^* P < 0.05 compared with sham. ^‡ P < 0.05 compared with CBDL. , control; , CBDL; , CBDL + splenectomy.

Inline graphic — The effects of spleen removal on pulmonary angiogenesis and gas exchange in experimental hepatopulmonary syndrome. Lung microvessels were stained by Factor VIII (in green) and counted in common bile duct ligation (CBDL) animals with or without splenectomy. (a) Representative immunofluorescent images of Factor VIII; (b) quantitation of Factor VIII‐stained microvessels; (c) graphical summaries of lung vascular endothelial growth factor‐A (VEGF‐A) mRNA levels; and (d) arterial gas exchange was assessed by the alveolar–arterial oxygen gradient (AaPO₂). Splenectomy significantly decreased lung microvessel numbers and VEGF‐A levels and improved AaPO₂ after CBDL. Values are expressed as means ± SE (n = 6–8 animals for each group). ^* P < 0.05 compared with sham. ^‡ P < 0.05 compared with CBDL. , control; , CBDL; , CBDL + splenectomy.