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. 2016 Nov 29;107(11):1705–1716. doi: 10.1111/cas.13075

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Representative immunohistochemical staining of JAG1 expression in human colorectal cancer tissues (original magnification ×100, scale bars represent 0.25 mm). (a) Example of cancer and endothelium tissue with weak intensity of staining (jcIHC‐W, jeIHC‐W). (b) Example of cancer and endothelium with moderate intensity of staining (jcIHC‐M, jeIHC‐M). (c) Example of cancer and endothelium with moderate and strong intensity of staining, respectively (jcIHC‐M, jeIHC‐S). (d) Example of cancer and endothelium with strong intensity of staining (jcIHC‐S, jeIHC‐S). (e) Example of poorly differentiated carcinoma with a strong intensity of staining. Representative each five regions in cancer or endothelium were indicated by open or filled arrow‐heads, respectively.