Table 2.
Univariate and multivariate analysis of factors associated with overall survival or relapse‐free survival
| Characteristics | Parameters | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | ||
| Overall survival (All patients, Cox model) | |||||||
| Sex | M vs F | 1.37 | 0.73–2.54 | 0.316 | 1.35 | 0.70–2.57 | 0.366 |
| Age | < 65 vs ≥65 | 0.96 | 0.52–1.78 | 0.906 | 0.99 | 0.51–1.93 | 0.980 |
| Histologic type | Well vs Others | 4.51 | 2.38–9.00 | <0.001** | 2.59 | 1.19–5.94 | 0.016* |
| T stage | T1,2 vs T3,4 | 3.91 | 1.56–13.07 | 0.002** | 1.47 | 0.51–5.31 | 0.497 |
| Lymph node metastasis | − vs + | 3.93 | 2.02–8.23 | <0.001** | 2.04 | 0.61–12.68 | 0.283 |
| Stage of tumor | 0/I/II vs III/IV | 4.08 | 2.03–9.08 | <0.001** | 1.02 | 0.14–4.31 | 0.980 |
| Lymphatic invasion | − vs + | 5.09 | 2.72–9.88 | <0.001** | 3.88 | 1.81–8.63 | <0.001** |
| Venous invasion | − vs + | 2.18 | 1.18–4.09 | 0.013* | 1.69 | 0.78–3.65 | 0.184 |
| JAG1 (Cancer) | W vs Mod/S | 3.99 | 1.71–11.62 | <0.001** | 2.62 | 1.10–7.74 | 0.027* |
| Relapse‐free survival (Patients besides Stage IV, Cox model) | |||||||
| Sex | M vs F | 1.58 | 0.78–3.13 | 0.226 | 1.21 | 0.54–2.63 | 0.643 |
| Age | <65 vs ≥65 | 1.66 | 0.83–3.42 | 0.138 | 2.10 | 0.99–4.62 | 0.055 |
| Histologic type | Well vs Others | 4.74 | 2.34–10.15 | <0.001** | 2.71 | 1.09–6.91 | 0.032* |
| T stage | T1,2 vs T3,4 | 2.40 | 1.06–6.44 | 0.035* | 0.92 | 0.33–2.77 | 0.870 |
| Lymph node metastasis | − vs + | 3.04 | 1.52–6.37 | 0.002** | 1.60 | 0.25–31.32 | 0.660 |
| Stage of tumor | 0/I/II vs III | 3.16 | 1.56–6.76 | 0.001** | 1.35 | 0.07–8.07 | 0.793 |
| Lymphatic invasion | − vs + | 4.56 | 2.29–9.20 | <0.001** | 4.47 | 1.76–11.57 | 0.002** |
| Venous invasion | − vs + | 2.07 | 1.03–4.12 | 0.033* | 0.51 | 0.19–1.37 | 0.184 |
| JAG1 (Cancer) | W vs Mod/S | 2.38 | 1.17–4.74 | 0.017* | 2.65 | 1.16–5.95 | 0.021* |
| Recurrence (All patients, Logistic model) | |||||||
| Sex | M vs F | 0.838 | 0.628 | ||||
| Age | <65 vs ≥65 | 0.369 | 0.080 | ||||
| Histologic type | Well vs Others | 0.003** | 0.082 | ||||
| T stage | T1,2 vs T3,4 | 0.272 | 0.354 | ||||
| Lymph node metastasis | − vs + | 0.006** | 0.712 | ||||
| Stage of tumor | 0/I/II vs III/IV | 0.005** | 0.035* | ||||
| Lymphatic invasion | − vs + | 0.031* | 0.471 | ||||
| Venous invasion | − vs + | 0.191 | 0.846 | ||||
| JAG1 (Cancer) | W/Mod vs S | 0.011* | 0.033* | ||||
*P < 0.05, **P < 0.01. CI, confidence interval; F, female; HR, hazard ratio; M, male; Mod, moderate; S, strong; W, weak.