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. 2016 Nov 29;107(11):1563–1571. doi: 10.1111/cas.13072

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Correlation between programmed cell death ligand 1 (PD‐L1) and CD8 in non‐small‐cell lung carcinoma (NSCLC) tissues. (a) Representative images of PD‐L1 and CD8 in tissues from patients with NSCLC by immunohistochemical staining. Images were taken at ×10 magnification. (b) Low CD8 expression rate was observed in patients with stable disease (SD) and high expression of this protein was seen in cases with partial response (PR). P < 0.0001. (c) PD‐L1 was negatively related to CD8 in these NSCLC tissues. P < 0.0001. (d,e) CD8 expression was associated with improved disease‐free survival (DFS) and overall survival (OS) of NSCLC patients after neo‐adjuvant chemotherapy in the survival curves. ORR, objective response rate.