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. 2016 Dec 1;11(12):e0167094. doi: 10.1371/journal.pone.0167094

Fig 5. Apoptosis induced by AS1411 in glioma cells.

Fig 5

(a) Apoptotic cell death induced by AS1411 in U87, U251, SHG44 and NHA cells. 48h after treatment, cells were collected and stained with PI and Annexin V–FITC, Annexin V-positive/PI-negative cells were measured by flow cytometry. This experiment was repeated three times. (b) Histograms showing the percentage of cells in apoptosis. U87, U251, SHG44 and NHA cells in four independent experiments. Annexin V-positive cells were considered as apoptotic cells. (c) Histograms showing the percentage of glioma cells apoptosis after the Bcl-2 overexpression and p53 siRNA silencing. Error bars indicate ± s.d. **P<0.01, two-tailed student’s t-test.