Table 2. CD36 receptor binding can be increased in laboratory strains but not in culture adapted field isolates.
strain | Binding/ 50 C32 nuclei before selection | Binding/ 50 C32 nuclei after selection |
---|---|---|
NF54 | 11 | 164 |
E5 | 12 | 232 |
MOA D2 | 2 | 11 |
MOA D5 | 15 | 1 |
MOA C3 | 0,7 | 15 |
Binding of the trophozoites to the CD36 receptor at the surface of C32 melanoma cells was quantified after several consecutive rounds of panning. The numbers depict the amount of bound Plasmodium trophozoites per 50 C32 cell nuclei. Adhesion of the laboratory strains NF54 and E5 was increased, but binding of MOA D2, D5 and C3 was not influenced.