Table 2.
Cdk5 substrates implicated in cancer
| Substrate | Site | Protein type/Cellular function | References |
|---|---|---|---|
| Akt | Ser-473 | Kinase/proliferation | [30] |
| AR | Ser-81, Ser-308 | Transcription factor/proliferation | [82] [30] |
| Ape1 | Thr-232 | Endonuclease/DNA Damage Response | [83] |
| ATM | Kinase/DNA Damage Response | [37] | |
| Caldesmon | Ser-527 | Cytoskeletal protein/Migration | [75] |
| DLC-1 | Ser-120, Ser-205, Ser-422, Ser-509 | Tumor suppressor/Proliferation | [84] |
| FAK | Ser-732 | Cytoskeletal protein/Migration/EMT | [15, 85] |
| Girdin | Ser-1674 | GTPase/Migration | [41] |
| Hu antigen R | Ser-202 | mRNA binding protein/Proliferation | [86] |
| Noxa | Ser-15 | Pro-apoptotic factor/Apoptosis | [79] |
| PAK1 | Thr-212 | Cytoskeletal protein/Migration | [87] |
| p53 | Ser-15, Ser-33, Ser-46 | Tumor suppressor/Apoptosis | [88] [89] |
| PIKE-A | Ser-279 | GTPase/Migration, invasion | [90] |
| Rb | Ser-780, Ser-795, Ser-807/811 | Tumor suppressor/Proliferation | [91] [23] |
| STAT-3 | Ser-727 | Transcription factor/Proliferation | [26] |
| Talin | Ser-425 | Cytoskeletal protein/Migration | [74] |
| VEGFR-2 | Ser-229 | Tyrosine kinase recptor/Invasion | [92] |