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. Author manuscript; available in PMC: 2017 Nov 23.
Published in final edited form as: Cell Syst. 2016 Nov 23;3(5):434–443.e8. doi: 10.1016/j.cels.2016.10.020

Figure 4. The models provide insights into the molecular basis of CHO-specific amino acid auxotrophies.

Figure 4

(A) Arginine, (B) Cysteine, (C) Proline, (D) Asparagine. For each reaction, information in the circles indicates whether the enzyme catalyzing the reaction is seen in transcriptomic (upper left quarter-circle) and/or proteomic (lower left quarter-circle) data, as well as its presence or absence in the cell line specific models generated by GIMME (right semi-circle). The square shows whether the enzyme catalyzing the reaction is seen in transcriptomic data from a mix of C. griseus tissues. Data used is available in Supplemental Data S4. Metabolite abbreviations are as follows: CITR-citrulline, ASP-aspartate, ARGSUCC-argininosuccinate, ARG-arginine, SER-serine, HCYS-homocysteine, CYST-cystathionine, ORN-ornithine, GLU-glutamate, GLU5SA-glutamate 5 semialdehyde, PRO-proline, GLN-glutamine, ASN-asparagine.