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. 2016 Dec 1;11(12):e0167474. doi: 10.1371/journal.pone.0167474

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© 2016 Zhang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 8 — MMP3 activates the canonical Wnt signaling pathway by cooperating with Wnt3a or antagonizing Wnt5b function, which is a non-canonical Wnt ligand and inhibitor of Wnt/β-catenin signaling. Biglycan enhances Wnt-induced β-catenin/TCF-mediated transcriptional activity via the LRP6 receptor.