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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Annu Rev Vis Sci. 2016 Jul 18;2:197–234. doi: 10.1146/annurev-vision-111815-114407

Figure 10.

Figure 10

Therapeutic strategies for treating retinal diseases. (a) Retinoid supplementation for diseases such as SFD affecting ROL delivery to the RPE or generation of a visual chromophore (LRAT or RPE65 RP/LCA). (b) Strategies to reduce the formation of excess atRAL, its lipid condensation products, or both, to facilitate their clearance from the eye. Abbreviations: LCA, Leber congenital amaurosis; LRAT, lecithin:retinol acyltransferase; NAD, nicotinamide adenine dinucleotide; RAL, retinal; RBP, retinol-binding protein; ROL, retinol; RP, retinitis pigmentosa; RPE, retinal pigment epithelium; SFD, Sorsby’s fundus dystrophy.