Table 1.

Key Characteristics of Thrombolytic Agents²³–²⁶

	Streptokinase	Urokinase	Alteplase	Reteplase	Tenecteplase
Generation	First	First	Second	Third	Third
Clot-specific?	No	No	Yes	Yes	Yes
Half-life (minutes)	12	7–20	4–10	11–19	15–24
FDA-approved for PE?	Yes	Yes	Yes	No	No

PE = pulmonary embolism; FDA = Food and Drug Administration.