Table 2.
Logistic regression analyses of correlations between RASSF1A rs2236947A/C, rs2073497A/C, rs1989839C/T, rs72932987C/T, and rs4688728G/T polymorphisms and risk of osteosarcoma.
| RASSF1A genotype | Cases (n=279) | Controls (n=286) | Crude OR (95% Cl) | P | Adjusted OR (95% Cl) | P | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| rs2236947A/C | ||||||||
| AA | 16 | 5.73 | 7 | 2.45 | 1.00 | 1.00 | ||
| AC | 51 | 18.28 | 53 | 18.53 | 0.42 (0.16–1.11) | 0.080 | 0.43 (0.16–1.13) | 0.086 |
| CC | 212 | 75.99 | 226 | 79.02 | 0.41 (0.17–1.02) | 0.054 | 0.43 (0.17–1.06) | 0.067 |
| AC+CC | 263 | 94.27 | 279 | 97.55 | 0.41 (0.17–1.02) | 0.055 | 0.43 (0.17–1.06) | 0.066 |
| AA+AC | 67 | 24.01 | 60 | 20.98 | 1.00 | 1.00 | ||
| CC | 212 | 75.99 | 226 | 79.02 | 0.84 (0.57–1.25) | 0.388 | 0.86 (0.58–1.29) | 0.470 |
| rs2073497A/C | ||||||||
| AA | 34 | 12.19 | 37 | 12.94 | 1.00 | 1.00 | ||
| AC | 113 | 40.5 | 128 | 44.76 | 0.96 (0.57–1.63) | 0.882 | 0.98 (0.58–1.67) | 0.935 |
| CC | 132 | 47.31 | 121 | 42.31 | 1.19 (0.70–2.01) | 0.523 | 1.18 (0.70–2.01) | 0.532 |
| AC+CC | 245 | 87.81 | 249 | 87.06 | 1.07 (0.65–1.76) | 0.788 | 1.08 (0.65–1.78) | 0.768 |
| AA+AC | 147 | 52.69 | 165 | 57.69 | 1.00 | 1.00 | ||
| CC | 132 | 47.31 | 121 | 42.31 | 1.22 (0.88–1.71) | 0.232 | 1.20 (0.86–1.69) | 0.278 |
| rs1989839C/T | ||||||||
| CC | 105 | 37.63 | 145 | 50.70 | 1.00 | 1.00 | ||
| CT | 133 | 47.67 | 109 | 38.11 | 1.69 (1.18–2.41) | 0.004* | 1.66 (1.16–2.38) | 0.006* |
| TT | 41 | 14.7 | 32 | 11.19 | 1.77 (1.05–2.99) | 0.034* | 1.74 (1.03–2.95) | 0.039* |
| CT+TT | 174 | 62.37 | 141 | 49.30 | 1.70 (1.22–2.38) | 0.002* | 1.68 (1.20–2.35) | 0.003* |
| CC+CT | 238 | 85.3 | 254 | 88.81 | 1.00 | 1.00 | ||
| TT | 41 | 14.7 | 32 | 11.19 | 1.37 (0.83–2.24) | 0.215 | 1.36 (0.83–2.23) | 0.228 |
| rs72932987C/T | ||||||||
| CC | 121 | 43.37 | 118 | 41.26 | 1.00 | 1.00 | ||
| CT | 104 | 37.28 | 122 | 42.66 | 0.83 (0.58–1.20) | 0.320 | 0.84 (0.58–1.21) | 0.341 |
| TT | 54 | 19.35 | 46 | 16.08 | 1.15 (0.72–1.83) | 0.571 | 1.15 (0.72–1.84) | 0.557 |
| CT+TT | 158 | 56.63 | 168 | 58.74 | 0.92 (0.66–1.28) | 0.612 | 0.92 (0.66–1.29) | 0.640 |
| CC+CT | 225 | 80.65 | 240 | 83.92 | 1.00 | 1.00 | ||
| TT | 54 | 19.35 | 46 | 16.08 | 1.25 (0.81–1.93) | 0.309 | 1.26 (0.81–1.94) | 0.307 |
| rs4688728G/T | ||||||||
| GG | 38 | 13.62 | 33 | 11.54 | 1.00 | 1.00 | ||
| GT | 94 | 33.69 | 116 | 40.56 | 0.70 (0.41–1.21) | 0.202 | 0.70 (0.41–1.20) | 0.193 |
| TT | 147 | 52.69 | 137 | 47.90 | 0.93 (0.55–1.57) | 0.791 | 0.92 (0.55–1.55) | 0.753 |
| GT+TT | 241 | 86.38 | 253 | 88.46 | 0.83 (0.50–1.36) | 0.456 | 0.82 (0.50–1.35) | 0.433 |
| GG+GT | 132 | 47.31 | 149 | 52.10 | 1.00 | 1.00 | ||
| TT | 147 | 52.69 | 137 | 47.90 | 1.21 (0.87–1.69) | 0.255 | 1.20 (0.86–1.68) | 0.276 |
*
Statistically significant (P<0.05).