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. 2016 Apr 29;124(12):1830–1839. doi: 10.1289/EHP212

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Effects of concentrated fine particulate matter (CAP) exposure on organ-specific insulin sensitivity. Western blot analysis of Akt phosphorylation in lung (A) and heart (B) and phosphorylation of Akt (i) and eNOS (ii) in aorta (C) and skeletal muscle (D) in mice injected with saline or insulin (1.5 U/kg). Mice fed control diet (10% kcal fat) or placed on a high-fat diet (HFD, 60% kcal fat) were exposed to air or CAP for 30 days (Study II). Data are the mean ± SE normalized to controls. NS, not significant. *p < 0.05 saline vs. insulin; ^# p < 0.05, ⁺ p < 0.1 air versus CAP; n = 4.