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. 2016 Apr 29;124(12):1830–1839. doi: 10.1289/EHP212

Figure 5.

Figure 5

Concentrated fine particulate matter (CAP)-induced vascular insulin resistance and inflammation are prevented in lung-specific ecSOD transgenic (ecSOD-Tg) mice. (A) Western blot analysis of the pulmonary ecSOD protein abundance (n = 4) in wild-type (WT) mice exposed to air or CAP for 9 days. (B) Western blots of the transgene ecSOD (t-ecSOD) protein abundance in lung and aorta isolated from WT mice exposed to air or CAP for 9 days and from ecSOD-Tg mice (Study V). Western blot analysis of the (C) pulmonary abundance of protein–acrolein adducts (loading controls are shown in Figure S4D, n = 4–5), (D) aortic insulin-stimulated Akt phosphorylation (n = 5–8) and (E) aortic IκBα abundance (n = 8–12) in WT and ecSOD-Tg mice exposed to air or CAP for 9 days. Data are the mean ± SE normalized to controls. *p < 0.05 control versus insulin; # p < 0.05 and + p < 0.1 air versus CAP.