Table 2.

Systematic Reviews and Meta-analyses Included.

	Type of Analysis	Findings
Sievenpiper et al. [76]	Aggregated randomized control trials looking at isocaloric exchange of either sugar or fructose with other macronutrients to assess effects on body weight in adults	No significant effect of either sugar or fructose on body weight
Te Morenga et al. [46]	Aggregated randomized control trials looking at isocaloric exchange of either sugar or fructose with other macronutrients to assess effects on body weight in adults	No significant effect of either sugar or fructose on body weight
Malik et al. [77]	Meta-analysis of 5 trials	2 of 5 trials resulted in significant weight loss from reducing sugar calories in one model but not another
Dolan et al. [78]	Normal weight individuals. Interventional Studies utilizing the FDA guidance for evidence based reviews	No difference with regard to obesity from fructose consumption in normal weight individuals
Dolan et al. [79]	Obese individuals. Interventional Studies utilizing the FDA guidance for evidence based reviews	No difference with regard to obesity from fructose consumption in obese individuals
Cozma et al. [82]	Systematic review and meta-analysis of 18 RCTs	Decrease in risk factors for diabetes such as glycosylated proteins
Malik et al. [24]	Meta-analysis of 8 cohort studies	4 did not find a significant effect of SSB on incidence of diabetes and 5 did not adjust findings for energy intake and body weight
Ha et al. [83]	15 studies involving 355 individuals	Slight decreases in diastolic and mean blood pressure and isocaloric substitution or hypercaloric trials