Table 8.
KEGG pathway analysis of genes that were significantly regulated in pterocarpan-high soy leaf extract supplemented subjects.
| KEGG Pathway | Downregulated Genes | Upregulated Genes |
|---|---|---|
| Cytokine–cytokine receptor interaction | CCR4, CCR6 | |
| Chemokine signaling pathway | CCR4, CCR6, LYN, RAP1B | |
| NF-κB signaling pathway | LYN, TRAF5, CCL4L2 | |
| Fatty acid metabolism | ACSL4 | |
| PPAR signaling pathway | ACSL4, PDPK1 | |
| AMPK signaling pathway | PDPK1 | |
| Insulin signaling pathway | PDPK1 | |
| FOXO signaling pathway | PDPK1 | ATG12 |
| Calcium signaling pathway | ATP2A2, SLC25A6 | |
| Pathway in cancer | TRAF5 | LPAR5 |
| PI3K–AKT signaling pathway | PDPK1 | LPAR5 |
Analyses were performed using KEGG pathway analysis (www.genome.jp/kegg) with genes that were differentially expressed pterocarpan-high extract, soy leaf extract supplemented subjects, compared with before pterocarpan-high soybean leaf extract supplementation. Genes up-, or downregulated in pterocarpan-high soybean leaf extract supplemented subjects compared with before pterocarpan-high soybean leaf extract supplementation; AMPK, AMP-activated protein kinase; KEGG, Kyoto Encyclopedia of Genes and Genomes; mTOR, mammalian target of rapamycin; TNF, tumor necrosis factor.