Table 4.

Linear regression analyses of the association of the two-year change in Hcy with the two-year change in depressive symptoms and HR-QoL (intention-to-treat).

	Crude Model a		Model 1 b		Model 2 (Fully Adjusted) c
	β (SE)	p	β (SE)	p	β (SE)	p
GDS-15 (subgroup of ≥5)	0.07 (0.06)	0.27	0.05 (0.06)	0.38	0.05 (0.06)	0.43
SF-12 PCS	−0.14 (0.03)	<0.001	−0.10 (0.03)	0.003	−0.09 (0.03)	0.01
SF-12 MCS	−0.05 (0.04)	0.18	−0.05 (0.04)	0.15	−0.05 (0.04)	0.13
EQ-5D Index	−0.003 (0.001)	<0.001	−0.003 (0.001)	<0.001	−0.002 (0.001)	0.004
EQ-5D VAS	−0.15 (0.06)	0.02	−0.09 (0.06)	0.16	−0.09 0.06)	0.16

^a Adjusted for baseline values of homocysteine and the respective outcome variable; ^b additionally adjusted for age, sex, and study center; ^c additionally adjusted for education level, smoking, alcohol use, creatinine, BMI, and MMSE. GDS-15: Geriatric Depression Scale, 15-item version; SF-12: 12-item Short-Form Health Survey; PCS: Physical Component Summary score; MCS: Mental Component Summary score; EQ-5D: EuroQol 5 Dimensions; VAS: Visual Analogue Scale.