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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Alcohol Clin Exp Res. 2016 Nov 2;40(12):2474–2481. doi: 10.1111/acer.13234

Figure 2. Effect of Alcohol on Folic acid pathways.

Figure 2

Representative diagram showing the interaction of ethanol (alcohol) on folic acid pathways. Folic acid is converted into tetrahydrofolate (THF) by the enzyme dihydrofolate reductase (DHFR). This THF is converted into methylene tetrahydrofolate (MTHF) by the cofactor vitamin B6. Again MTHF is transformed to THF by the key enzyme, MTHF reductase (MTHFR). In this diagram, the authors speculate that ethanol may inhibit the folic acid to DHF conversion and methionine synthase activity.