Table 3.
Pathways under-represented among patients in cohort two.
| Pathway | Overlap size | Pathway size | p-value |
|---|---|---|---|
| NEGATIVELY CHARGED IONS | |||
| Urea cycle/amino group metabolism | 3 | 21 | 0.0106 |
| Biopterin metabolism | 2 | 7 | 0.01162 |
| Tryptophan metabolism | 3 | 37 | 0.03769 |
| Glycerophospholipid metabolism | 2 | 16 | 0.03784 |
| POSITIVELY CHARGED IONS | |||
| N-Glycan biosynthesis | 2 | 3 | 2.00E-05 |
| Drug metabolism - cytochrome P450 | 5 | 30 | 2.00E-05 |
| Ubiquinone Biosynthesis | 2 | 5 | 9.00E-05 |
| Hexose phosphorylation | 2 | 7 | 0.0003 |
| Linoleate metabolism | 2 | 7 | 0.0003 |
| Histidine metabolism | 2 | 11 | 0.00218 |
| Galactose metabolism | 2 | 15 | 0.00922 |
| Squalene and cholesterol biosynthesis | 2 | 15 | 0.00922 |
| Glycerophospholipid metabolism | 2 | 18 | 0.02106 |