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. Author manuscript; available in PMC: 2017 Dec 15.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Jun 1;107:176–191. doi: 10.1016/j.addr.2016.05.020

Table 3.

Advantages and limitations of PLA micro and nano-particles [8].

Advantages Limitations
Micro-particles Subcutaneous injections
Intramuscular injections
Controlled release
Reproducible processes		 Unintended toxic side effect due to high initial burst

Wasteful use of expensive drugs due to initial burst
release
Nano-particles Direct injection to the blood

Potentially improved vaccine responses		 Non-specific uptake by reticuloendothelial system
(RES) systems
Potential immunotoxicity