FIGURE 1.

Schematic diagram illustrating the possible outcomes of a Caenorhabditis elegans-based anti-infective screen. From a screen, the compounds can be categorized as those with possible toxic effect, potential anti-infective effect or no effect. The hits that promote the survival of C. elegans following an infection can either act as anti-microbial, anti-virulence, or immunoactivator/immunomodulator. The toxic effect of a compound can be further validated by exposing the worms to the particular compound in an uninfected condition where the worms are fed with dead Escherichia coli OP50.