Table 1.

Additional drugs/compounds evaluated for in vivo antimicrobial effects using a Caenorhabditis elegans model.

Drugs/compounds	Description	Infection model	Reference
Celecoxib	An FDA-approved non-steroidal anti-inflammatory drug that blocks the COX-2 enzyme. It is used to relieve fever, pain and inflammation.	C. elegans – MRSA	Thangamani et al., 2015
Lamotrigine	An FDA-approved anticonvulsant drug that also inhibits ribosome biogenesis in bacteria, thereby preventing the growth of bacteria.	C. elegans–Salmonella enterica	Stokes et al., 2015
Auranofin	A form of gold complex that is mainly implicated in the treatment of rheumatoid arthritis.	C. elegans–S. aureus	Fuchs et al., 2016
Artilysins	A modified form of endolysins, enzymes produced by bacteriophages to hydrolyze the bacterial cell wall, with improved outer membrane-penetrating capability.	C. elegans–P. aeruginosa	Briers et al., 2014
Berberine derivatives	Berberine is a natural alkaloid found in plants.	C. elegans–E. faecalis C. elegans – MRSA	Tomkiewicz et al., 2010 Dolla et al., 2015